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| Brand Name: | LIBANG |
| MOQ: | 50 kg |
| Payment Terms: | T/T, L/C |
| Supply Ability: | 50000 kg per year |
Amidotrizoic Acid Dihydate API EP CAS No.50978-11-5
International Nonproprietary Names (INN): Diatrizoic Acid
Compendial name, given in EP: Amidotrizoic Acid
Compendial name, given in CP: Diatrizoic Acid
USAN name: Diatrizoic Acid
Chemical name: Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-.3,5-Diacetamido-2,4,6-triiodobenzoic acid
Description: White powder.
Solubility: Very slightly soluble in water; soluble in ammonia solution or sodium hydroxide solution.
Fuction: Amidotrizoic Acid Dihydate is used for producing the radiopaque contrast agent for intravascular use named as Diatrizoate Meglumine and Diatrizoate Sodium Injection or Diatrizoate Meglumine Injection.
Mechanism of action
Diatrizoate is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.
| TEST | SPECIFICATION | RESULT |
| Appearance | White, odorless powder |
Conforms |
| Identification | (1) It responds to the Thin-Layer Chromatographic Identification Test | Conforms |
| (2) Positive reaction | Conforms | |
| Water | 4.5%~7.0% | 5.6% |
| Residue on ignition | NMT0.1% | 0.06% |
| Iodine and iodide | NMT 0.02% of iodide |
Conforms |
| Heavy metals | NMT 0.002% | Conforms |
| Free aromatic amine | NMT 0.05% | 0.008% |
| Ethyl alcohol | NMT 0.5% | Not detected |
| Acetic acid | NMT 0.5% | Not detected |
| Bacterial endotoxins | NMT 1.5 EU/g | ＜1.5 EU/g |
| Microbial Limit | Total aerobic microbial count: ＜1000 cfu/g | Conforms |
| Total yeast and molds count: ＜100 cfu/g | Conforms | |
| Assay | 98.0%～102.0%(Calculated on the anhydrous basis) | 99.2% |
Xi'an Libang Pharmaceutical Co., Ltd. was established in 1996, It is a professional Manufacture specializing in pharmaceutical raw materials and Finished dosage form. The company has gathered a dedicated and professional sales and technical personnel. We have a marketing team with first-class efficiency and first-class service! Strong technical force, high quality and low price products, first-class marketing and after-sales service are your best choice!
